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After deep intramuscular injection the lipophilic ester diffuses slowly from the oil depot, undergoes enzymatic cleavage to free testosterone and enters the systemic circulation, where roughly 98 % is reversibly bound to sex-hormone-binding globulin and albumin while the unbound fraction translocates across cell membranes to activate androgen receptors. Deep intramuscular administration into the gluteal muscle using a 22-gauge needle is recommended, and patients who self-inject must be trained in aseptic technique, site rotation and safe sharps disposal to reduce infection and tissue-injury risk. 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